One of the most powerful inhibitors of the inflammatory process in the body is a glucocorticosteroid drug Prednisone. It is used in the treatment of systemic diseases such as antishock means, as well as an inhibitor of allergic reactions.
The mechanism of action. Stabilizer of cell membranes. Inhibitor of the synthesis of prostaglandins and leukotrienes. It reduces vascular permeability, inhibits the degranulation of basophils. The immunosuppressant. It has catalytic and hyperglycemic action. The drug increases blood pressure by delaying sodium and calcium excretion.
Pharmacokinetics. It is quickly absorbed by ingestion. The maximum concentration in blood is determined through 1-2 hours after reception. The metabolism of Prednisone is held in the liver. It is excreted in the urine.
Application and dosage. Ingestion. The starting daily dose for adults is 20-30 mg, for children – 1-2 mg/kg. Therapeutic dose for adults is 5-10 mg/day and for children it is 300-600 mg/kg. The maximum daily dose of Prednisone for adults is 100 mg, a single maximum dose is 15 mg. Daily dose is divided into 4-5 receptions, the highest dose was in the morning, the smallest one was at night.
- systemic pathology of the connective tissue and joints;
- bronchial asthma;
- allergic reactions;
- brain edema;
- adrenal insufficiency;
- autoimmune diseases;
- immune suppression according to indications.
- diseases of the digestive tract;
- cardiovascular disease;
- endocrine disorders;
- endocrine disorders;
- “steroid” sores;
- pathology CCC;
- the leaching of calcium;
- disorders of the nervous system;
- slowing of wound healing;
- the closure of the growth areas.
Synthetic glucocorticoids are more active than natural one, so you should use them with extreme caution. Before buying Prednisone, you should consult a specialist who will choose the optimal scheme and the duration of treatment.
The drug has a significant effect on protein, carbohydrate, mineral and fat metabolism in the body. The uncontrolled treatment may lead to muscle weakness, increases the content of glucose in the blood, deteriorating the absorbability of calcium that leads to brittle bones and also other side effects. In case of clear indications and the appointment of an adequate dose, which depends on the type of disease and condition of a patient, the positive effect exceeds the risk of side effects.