Nexium (Esomeprazole)



Unhealthy lifestyle leads to ulcers of the stomach and duodenum. We mean not only harmful habits (smoking and alcohol abuse), as well as abundant frequent consumption of sweets, soda, caffeinated drinks, irregular meals, spicy, sizzling or very cold food, constant intake of anti-inflammatory medications, frequent depression and stress. In this case, a person needs to reconsider their lifestyle and habits, as well as to undergo treatment, an integral part of which is a drug Nexium. The instruction for use of this medication indicates the need to take it only under medical supervision.

Release form and composition

Nexium belongs to the group of inhibitors of H+-K+-ATPase. It is available in two forms – in pill form (20 and 40 mg) and lyophilisate (40 mg, compressed weight) to prepare a solution, which is injected intravenously. The active ingredient of both forms is esomeprazole sodium.

Pharmacological action

Pharmacological action of tablets and lyophilisate is identical. The drug reduces stomach acid secretion. The effect of the medicine comes rather quickly – within the hour. When it is taken regularly, during the week the level of acid in the stomach is reduced by 90%. Relief was observed in patients in 78% of cases. If the ulcer is uncomplicated, subsequent therapy is not needed. In more complex cases it is necessary to carry out the treatment on ulcer healing. However, it should be noted that in severe ulcer disease that is accompanied by bleeding, Nexium is also effective.


Now we’ll describe the dosage reception of pills. Children over 12 and adults are recommended to follow the following scheme. In the case of gastroesophageal reflux disease the drug is taken only once per day in amount of 40 mg. But you should take it the whole month. Support course, which can last long enough, implies taking 20 mg once a day.

As for stomach ulcers and 12 duodenal ulcer, Nexium is used in the combined therapy prescribed in a dose of 20 mg to be taken two times a day for weeks. In severe peptic ulcer bleeding, Nexium should be taken at a dose of 40 mg once a day throughout the month. Ulcer prevention involves the reception of the medicament in a daily dosage of 20 mg.

Lyophilisate is an alternative if you cannot use tablets. It is intended for adults only. The maximum daily dose is 40 mg. It is injected intravenously. Unlike the oral variant of this drug, lyophilisate is characterized by a brief period of action. Moreover, the fact is that there’s a faster action.

Indications for use

Nexium is indicated for symptomatic treatment of gastroesophageal reflux disease, treatment of erosive reflux esophagitis, gastric ulcer and 12 duodenal ulcer, prevention of recurrence, in case of ulcer healing. In turn, lyophilisate is prescribed in case of reflux disease, with the goal of healing and prevention of peptic ulcers and recurrent bleeding.

Drug contraindications

Contraindications include age under 12 years, incompatibility with products containing nelfinavir and atazanavir, high susceptibility of components of the drug. When treating patients with renal and hepatic insufficiency you need to use Nexium very carefully. The instruction for use of medicines, in turn, recalls that during pregnancy and lactation, a decision on the appointment of the drug should be taken by a doctor as there is a risk for children.


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