Zoloft (Sertraline)



Pills Zoloft are antidepressant, which is used for the prevention and treatment of certain diseases of the nervous system. The active ingredient of the drug is sertraline. It inhibits the reuptake of serotonin by neurons, making the patient no longer experience a deficiency in serotonin. The description of action of Zoloft notices that its application gives a sedative effect, and the existing reviews of Zoloft show that the drug improves mood, reduces appetite, and removes the alarm. Such action causes the use of Zoloft in the treatment of depression and manic states.

Zoloft is used to treat symptoms of depression, which is accompanied by a feeling of anxiety in the presence or absence of mania in history.

After obtaining a satisfactory effect, the continuation of treatment with sertraline can prevent the relapse of the initial episode of depression and their occurrence in the future.

Zoloft is indicated for the treatment of OCD – obsessive-compulsive disorder.

After receiving the initial effect of prolonged treatment with sertraline, there was observed persistent efficacy, safety and tolerability, at least for 2 years. Zoloft is indicated for the treatment of OCD of children.

Zoloft is also used to treat panic disorders with or without fear of space. Zoloft is indicated for the treatment of post-traumatic stress disorder (PTSD).

Zoloft is indicated for the treatment of social anxiety disorder. In case of a satisfactory response for treatment, the continuation therapy with Zoloft is effective in preventing relapse of the primary manifestations of social phobia.

How to use Zoloft

Method of application and doses.

Zoloft is prescribed 1 time per day in the morning (if possible) or in the evening. Pills of Zoloft can be taken independently from eating.

  • The beginning of the treatment.
  • Depression and OCD .
  • Treatment with sertraline should be started at a dose of 50 mg/day.

Panic disorder, PTSD, and social phobia. Treatment should be initiated with a dose of 25 mg/day. After 1 week the dose should be increased to 50 mg 1 time a day. Such a dosing regime reduces the incidence of side effects in the initial phase of treatment of panic disorder.

The use by children.

The safety and efficacy of sertraline was demonstrated by children with OCD, aged 6 to 17 years. Sertraline is used by children with IPD aged 13 – 17 years with a dose of 50 mg/day.

Treatment of children aged 6 – 12 years should start with a dose of 25 mg/day with subsequent increase up to 50 mg/day after 1 week of treatment. In case of absence of effect from a dose of 50 mg/day you may further increase it to 200 mg/day (if necessary). During clinical trials of children aged 6 – 17 years with depression or vdcs, the pharmacokinetic characteristics of sertraline was similar to the same one of adults. However, if you increase doses over 50 mg in pediatrics, you should take into account the lower overall body weight of children compared to adults.

Side effects of Zoloft

Side effects that occur in multi-dose studies of depression occurred significantly more often in the sertraline group compared to placebo.

  • Autonomic nervous system: dry mouth, excessive sweating.
  • Central and peripheral nervous system: dizziness, tremor.
  • Gastrointestinal tract: diarrhea/urinary emptying, dyspepsia, nausea.
  • Psyche: anorexia, insomnia, drowsiness.
  • Reproductive system: sexual dysfunction (primarily delayed ejaculation in men).

The range of side effects that are often observed to double-blind people, in placebo-controlled trials of patients with LSC, panic disorder, PTSD and social phobia was similar to that observed in clinical studies in patients with depression.

Who should not use Zoloft

Sertraline is contraindicated to patients with known hypersensitivity to the drug.

Concomitant use of sertraline with a monoamine oxidase inhibitors (MAOIS) is also contradicted.


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